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Virtual Screening (VS) is one of the latest advances supporting new drug discoveries. The in-silico technique allows a better selection of molecules with the desired chemical characteristics, reducing characteristics, and reducing the number of experiments, including in animals, to search for the most probable drug candidates among an extensive library of compounds. Generally, proprietary software for VS has a high cost, which makes its use unfeasible in some scenarios. On the other hand, the free tools used for this purpose are often complicated and do not even have a graphical interface. In this context, this study presents Mini-Docking, free software with a simple and intuitive interface that automates VS experiments. Mini-Docking integrates the following tools: Dock6, MGL Tools, Chimera, and Autodock Vina. In contrast to other platforms, Mini-Docking can simulate fitting an unlimited number of compounds into a set of molecular targets. The main advantages of Mini-Docking over Dock6, MGL Tools, Chimera, and Autodock Vina are its automation, ease of use, speed, and error reduction. However, a human operator must manage the four programs mentioned if Mini-Docking is not used. Furthermore, the output of one program must be used as input to the next program, which frequently requires user action, introducing delays in the VS process and the possibility of user-generated errors. Therefore, there is also a need to check for human mistakes at every step that requires user action. In addition, the user needs to perform user action steps for each target ligand combination. However, in Mini-Docking, as soon as one of the programs completes, the next one runs automatically without user intervention. Consequently, Mini-Docking reduces the possibility of user-generated error because it reduces human interactions. In the Mini-Docking workflow, the Chimera is used to prepare molecules. In the next step, the MGL Tools determine the rotation ligations and bonding and assign Gasteiger-Marsili net atomic charges. Then, the Autodock Vina performs the first molecular docking, with your output used as input of Dock6. So, Dock 6 executes molecular docking with the production of Dock6. The results are computed and presented to the user in the last step. In conclusion, the Mini-Docking has a simple workflow that requires minimal user action to perform in the VS process since the molecular preparation for the docking process. Therefore, it helps the user automate the process and minimizes errors during the process. It also avoids the need to know diverse file formats and forms of execution of the programs used in Mini-Docking. At last, Mini-Docking is available for download free of charge at https://www.drugdiscovery.com.br/software/.

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1	Lucas Medaglia(Dummy_email@email.com)
2	Tiago Oliveira(Dummy_email@email.com)
3	Eduardo Maia(Dummy_email@email.com)
4	Alisson Silva(Dummy_email@email.com)
5	Alex Taranto(Dummy_email@email.com)

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